major basic protein การใช้

Major basic protein, eosinophil peroxidase, and eosinophil cationic protein are toxic to many tissues.
The eosinophil major basic protein also causes the release of histamine from mast cells and basophils, and activates neutrophils and alveolar macrophages.
Structurally the major basic protein ( MBP ) is similar to lectins ( sugar-binding proteins ), and has a fold similar to that seen in C-type lectins.
Cardiac damage caused by the damaging effects of eosinophil granule proteins ( ex . major basic protein ) is known as Loeffler endocarditis and can be caused by idiopathic eosinophilia or eosinophilia in response to parasitic infection.
Major basic protein induces mast cell and basophil degranulation, and is implicated in proliferation of T cells, suppress antibody production by B cells, induce degranulation by mast cells, and stimulate fibroblast cells to secrete mucus and glycosaminoglycan.